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The presence of the tetracycline or tet analog and the revTetR at this sub-lethal, preferably sub-inhibitory, concentration reduces the amount of the proliferation-required gene product to the lowest level that will support growth of the cells!
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Alkenyl substituted 4-dedimethylamino tetracycline compounds, nurofen usa such as 7-alkynyl 4-dedimethylamino sancycline (4A) and 7-alkenyl 4-dedimethylamino sancycline (4B), can be hydrogenated to form alkyl substituted 4-dedimethylamino tetracycline compounds (eg, 7-alkyl 4-dedimethylamino sancycline, 4C)! In a preferred embodiment, nurofen usa the nucleotide sequence encoding the revTetR repressor is selected from nucleotide sequence encoding any of the amino acid sequences of SEQ ID NOS!